Grape honeysuckle is a twining woody vine, sometimes somewhat bushy when no support is present.
Flowers in clusters at the end of stems on new growth; clusters arranged in 2–6 whorls or layers, which are usually separated along the stalk; flowers pale yellow, fragrant, ¾–1 inch long, tubular, slender, noticeably enlarged on one side at the base, smooth on the outside, hairy inside; tip of tube strongly spreading into 2 lips, one lip with a single narrow lobe, the other lip with 4 short lobes; stamens protrude beyond flower. Blooms April–June.
Leaves simple, opposite, connected by a broad base, pointed, the upper surface with a white (glaucous) coating. The inflorescence is subtended by a pair of leaves connected to form a disk about 6 inches long and 2 inches wide.
Fruits crowded in heads at the ends of stems; clusters arranged in 2–6 whorls or layers, which are usually separated along the stalk; berries red to orangish red, globe-shaped, about ¼ inch across, fleshy.